Featured Structure

Histidine phosphatase of Sts-1 showing active site histidines (ball and stick) and sulfate bound in active site (5VR6)

The suppressor of T-cell signaling (Sts) class of proteins has emerged as a potentially important target for immune regulation. Work from our collaborators lab has shown that mice lacking the Sts-1 and Sts-2 proteins are profoundly resistant to infection by deadly pathogens, including C. albicans. The structure above (solved at 1.87 Å) shows the histidine phosphatase domain of human Sts-1 in complex with sulfate. Structures of this catalytic domain of Sts-1 form the foundation of a long-term, structure-guided drug discovery program aimed at developing immuno-stimulatory therapies to treat deadly pathogen infections.